Aspirin melting point purity. Aspirin Melting Point Analysis 2022-10-25
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Aspirin, also known as acetylsalicylic acid, is a commonly used pain reliever and anti-inflammatory medication. It is widely available in both prescription and over-the-counter forms, and is often used to treat a variety of conditions including headaches, muscle pain, and inflammation.
One important aspect of the production and quality control of aspirin is its melting point. The melting point of a substance is the temperature at which it changes from a solid to a liquid. Aspirin has a melting point of approximately 136-138°C. This is a key characteristic that is used to determine the purity of the substance.
To determine the melting point of aspirin, a small sample is placed in a melting point apparatus and heated slowly. As the temperature increases, the aspirin will begin to melt at its melting point. The temperature at which the melting occurs can then be recorded and compared to the known melting point of pure aspirin. If the measured melting point is close to the known value, it is an indication that the sample is pure. However, if the melting point is significantly different, it may indicate the presence of impurities in the sample.
Purity is an important factor in the production of aspirin because impurities can affect the safety and effectiveness of the medication. For example, impurities may alter the rate at which the aspirin is absorbed by the body, or they may interact with other medications in a way that could be harmful to the patient. Ensuring the purity of aspirin is therefore a critical aspect of its production and quality control.
In conclusion, the melting point of aspirin is an important characteristic that is used to determine the purity of the substance. Ensuring the purity of aspirin is essential for the safety and effectiveness of the medication, and the melting point is a key tool in the quality control process.
Aspirin: Identification and test for purity: Pharmaceutical Chemistry Practical
. Seek medical attention if the victim shows drunken symptoms or if methanol or methylated spirit is involved. Salicylic acid is derived from the bark and leaves of the willow tree. The melting point of salicylic acid is 158-161 degrees Celsius. If vapour inhaled move the victim to fresh air to rest.
Crystal field theory describes the breaking of d or f orbitals, due to a static electric field produced by anion neighbors in my case the negative oxygen in the phenolic group of the aspirin. The solid was the crude product which released a noticeable smell of vinegar. Take readings every 30 seconds and record them in a table. The disadvantage of this method is that most of the excess reactant is left unreacted, requiring extra steps to remove it that I will address below. Making sure the joint is air tight. The structure of methyl-2-hydroxybenzoate is shown on the right, and is an ester as it has the functional group —COO-.
Add roughly half a spatula of anti-bumping granules. By summing the values of all the superscript numbers, we can see that an Fe atom has 26 electrons. For publisher information, see ARTODN. The precipitate was dried in an oven for five minutes. Next, a small sample of the recrystallized aspirin was taken and put in a capillary tube. I'm sure it is a simple calculation, but i can't figure out how to do it. It is safe to conclude that the presence of impurities will reduce the melting point of synthesized aspirin samples.
How Spectrophotometers Can Ensure the Purity of Aspirin
The known melting point range for acetyl salicylic acid is 135°C -136°C. However, caution was taken in handling the phosphoric acid to avoid chemical burns. Oil of wintergreen is 98% methyl 2-hydroxybenzoate and is what I used as my starting chemical. Conclusion The purity of our crude and recrystallized aspirin samples were quantitatively measured by determining their respective melting point temperature ranges. The aspirin product obtained in the reaction and is compared to standardized 0. Emergency procedures: If swallowed wash out the mouth and give a glass of water and Seek medical attention as soon as possible. Equipment List UV light source Dropping tubes Silica coated t.
I also sent my sample of Aspirin to GSK for NMR Nuclear Magnetic Resonance spectroscopy. Sulfuric acid H2SO4 is used as a catalyst for the reaction and accelerates the rate at which the aspirin is formed. Wash the product with a small amount of cold solvent and transfer it to a pre-weighed watch glass so you can minus the weight of the watch glass when calculating percentage yield. Seek medical attention if breathing is at all affected. This means that larger molecules will take longer to move through the drift region. I used 50cm3 volumetric flasks to measure out 50cm3 of 95% ethanol and then added it to each of the conical flasks. The actual yield of pure aspirin was 2.
Preparation of Aspirin and Determination of the Melting...
This process allows the reaction to be heated over a period of time, without evaporating away the solvent or reactants. Phenolphthalein indicator takes advantage of the fact that aspirin is an acid. Drift Region: All the air molecules in the drift region have been pumped out creating a strong vacuum. Conclusion In a conclusion, the objective of this experiment was met by testing the purity of the end product 136. Then, the excess acetic acid is quenched with water. The melting point of the aspirin was found to be 110-115 degress Celsius. Therefore, impure aspirin melts at a lower temperature than pure aspirin with no impurities present.
Synthesis of Aspirin & Determination of Product Purity
To this end, phosphoric acid served the purpose perfectly. It has the ability to reduce fever an antipyretic , to reduce pain an analgesic , and to reduce swelling, soreness, and redness an anti-inflammatory agent. Set up Hirsch funnel and suction apparatus same as Buchner funnel and suction apparatus diagram above but with a Hirsch funnel. The melting points for the acidic and neutral compounds were hence too low, and the melting point for the basic compound was too high. .
Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK V. To hydrolyse the methyl-2-hydroxybenzoate it is heated under reflux with the dilute alkali sodium hydroxide. Rinse the area with water and wipe up, rinsing repeatedly. When the light on the green button is green and all the absorbance values on the screen are 0 then you have calibrated the colorimeter. Aspirin is a pain reliever and a fever reducer and when it is ingested it is broken down to salicylic acid in the …show more content… The purity of the synthesized aspirin is analyzed next.
The 100 Most Important Chemical Compounds. In this arrangement, the attractive forces between the molecules are maximized and uniform. Among the side effects include; ringing in the ears and stomach bleeding. If splashed in eye flood the eye with gently running tap water for 10 minutes and seek medical attention. The atoms have different energy gaps between their high and low energy levels and so absorb different frequencies of radiation.
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